I used the Phlster Skeleton the other night. I carried at my 4 oclock. This position is good when being seated for a while. We went to my in-laws for Chinese New Years. So printing wasn't a concern, but comfort is. Each carry position has it's pro's and cons. See below:
AIWB:
Pros:
1) More concealable
2) Faster draw
3) Easier draw when seated, esp in the car
4) Better control/retention if someone tries to grab it
Cons:
1) Digs in when seated
2) Digs in a lot when seated for long periods
3) Need to offset belt buckle (not a huge deal, but when buying a belt, the nicenesss of how the buckle looks doesn't matter)
4) When bending over, like tying shoelace or picking something off the floor, it's in the way
5) After a big meal, stomach pushes holster out more
4 O'Clock IWB
Pros:
1) Comfort when seated
2) Ease to pick stuff up (see above con for AIWB)
3) Belly size doesn't really matter
4) Can take a dump quicker (leave gun on belt, compared to AIWB, need to remove entire holster)
Cons:
1) Slower draw
2) More difficult retention if someone tries to grab it
3) Printing more, esp when leaning forward. Like on a stool eating or at a table game in Vegas
4) Takes much more effort to draw when in a car (seatbelt in the way, driver side) or when seated (you may be sitting on your shirt, which prevents the lifting of it to clear the firearm)
5) No side car on the holster, so spare mag needs to be else where
There might be more, but so far, this is my XP.