It makes no difference in the cosmos unless you want it to. Anyone who truly thinks this is meaningful in anyway is just looking for an excuse to not like someone as a candidate because they can't wrap their mind around something logical to not like about a candidate. So they look for a feeling to not like him. It doesn't mean a thing about how someone is going to perform at their job. It is nothing more than another form of prejudice.

This thing you call an article is nothing more than a hack job on Cruz. It is as obvious as the line we have to stand in to register our guns. They can't attack him on his politics or his religion so they attack his looks. People who believe this crap and vote against Cruz just for this reason deserves another 8 years of other POS like Obama, Hillary and Bernie. Morons. What a bunch of BS.

Ok, I don't think this is all some conspiracy attack ad. As a student of sociology and psychology, as well as a fan of those sciences I can tell you that these things are real. The human brain looks at facial features since they are a form of communication, and it does it incredibly fast. This is a survival mechanism to help determine whether a person is friend, foe, or something else. Certain facial expressions are associated with certain reactions and when something doesn't fit, it stands out as different which raises the alert level.
Sometimes these cues are obvious and we know why they make us dislike a person. Say for example someone grinned upon hearing the news your child died today. You would recognize this as inappropriate and easily be ablate explain why.
Sometimes the cues are not so obvious and though your subconscious recognizes it, your conscious side does not. Perhaps you are walking down the street and someone passes you by and you get an uncomfortable feeling. You know you feel uncomfortable around that person but you cannot explain why.
This sort of subconscious weariness of an individual will affect our actions through the survival mechanism and voting for candidates for office is not immune to this mechanism. It almost certainly affects the way some people vote. Maybe even just on a small level, like deciding between two candidates with similar positions.
Now this is not to say you cannot overcome this mechanism, but not everyone will try or even recognize it to try and overcome it. You can force yourself to talk to that person on the sidewalk who gave you an uncomfortable feeling but many won't.