(disclaimer not a scientist, but saw one posting this) #trustscientists
Hydroxychloroquine proposed mechanism of action: Hydroxychloroquine is known to break the early/late endosome. Many viruses use the endosome as a method of penetrating a cell, and take advantage of the acidic endosome to activate. Hydroxychloroquine effectly blocks the viruses ability to enter and activate intracellularly (in theory).
Hydroquine toxicity: cells use endosomes and exosomes to shuttle around proteins, signal other cells, and for immunity. Hydroxychloroquine significantly affect's the cell's ability to properly use endosomes, leading to impaired cellular signaling, reduced immunity, and impairs just about any biological pathway that uses endosomes (a lot!).
Ivermectin proposed mechanism of action: Ivermectin is a macrocyclic small molecule drug. Macrocyclics are drugs that are arranged in a ring. In many cases, the centers of these rings can work like a jig-saw puzzle, and grab parts of cells, proteins, or other molecules within their hole. Ivermectin is proposed to disrupt Covid's ability to bind to the ACE-2 receptor. Most likely, Ivermectin binds to the ACE-2 receptor first, preventing the COVID virus particle from docking with the ACE-2 receptor.
Ivermectin toxicity: Ivermectin is known to bind with high affinity to chloride ion channels in parasites:
https://web.stanford.edu/group/parasites/ParaSites2005/Ivermectin/mechanism%20of%20action.htm. Unfortunately, evolution often conserves protein structure across species. We can infer that Ivermectin will also bind to human ion gated channels, but at lower binding affinity. When overdosing on Ivermectin, we can expect human ion gated channels to be blocked. Ion gated channels are required for neuron signaling. Blocking these will prevent your neurons from functioning.
In layman's speak, Ivermectin should work as a neurotoxin. We can see this in recent toxicity reports:
https://www.medpagetoday.com/infectiousdisease/covid19/94223. Hallucination, seizures, coma, and tachypnea, and tremors: all neurological. We also see gastointestinal issues: nausea, diarrhea, abdominal pain, etc. This is the body's natural defense against ingested toxins. We can also expect liver damage, as the body is recognizing Ivermectin is a toxin. This means that the majority of Ivermectin will be absorbed by the liver, before it can reach your cells.