I'd go with Dave's suggestion on checking headspace. The brass is pre-processed, so they are probably sized to minimum size so that they'll work in any chamber. Maybe a few are too short, base to shoulder. That could happen with application of too much lube, especially if the die is already set to size the maximum amount.
Also, rem700s are not known for tightest of chambers. That's not a necessarily a bad thing. But just something that one should be aware of.
Was the rounds being fired one right after another? Did you chamber any rounds in the hot rifle and have it sitting for a few minutes before breaking the shot?
Having a hot rifle isn't necessarily a bad thing for load development, however, I don't like to have rounds sitting in the hot chamber too long before breaking a shot. I usually chamber the round right when I'm ready to shoot. I actually want the barrel to be hot during LD, That way I can find the most consistent load for cold bore and hot as well.
I think your 45.5 load is the sweet spot for your rifle. Slight adjustment of seating depth in .002" increments will find the tightest groups in no time.