Are you interested in an actual pistol SAFE or just something to deter casual unauthorized access?
Depending on how much you are willing & able to spend, there are some out there that are made of the same, or better, steel as long gun safes. They have a variety of locking mechanisms, too.
I went with FAS1 safes. I have 3, all in different rooms. They added the key lock option a couple of years ago, so I ordered one of them as my third.
From what I can tell, they are in the same class as some of the Fort Knox models, but with more size and feature options.
The owner/manufacturer works with you on shipping, since HI is way more expensive (these things are H-E-A-V-Y). All of mine were purchased during one of his holiday promos, which originally saved me the shipping cost. Unfortunately, shipping has gone up, so now it's a bit more overall to ship here.
If you're curious, try signing up for his promo emails. Then you can see what discounts roll around. He also posts to FB and Twitter, it you'd rather just subscribe there.
Here's a pic of my bedroom safe:

You can position the safe vertically or horizontally as long as you have clearance for the lid. Holster presents the pistol upon opening with the aid of some REALLY STRONG hydraulic struts, and the safe and holster sizes can be selected for your handgun sizes.
If you buy your safe one size or more larger than you need for your HD pistol, you'll have room for extra mags, another pistol or two, valuables, etc. I put extra mags in mine without having to "upsize."
http://www.fas1safe.com/