For the most part, I don't care for the .380. It's generally unimpressive ballistics and the propensity of manufacturers to only make elfin models means that it has very little use on a target range, which is where I spend most of my time.
The small guns are fairly brutal in terms of recoil, not horribly accurate, and rather uncomfortable for someone with largish hands to operate.
However, IF I were allowed to carry a concealed gun... suddenly the .380 looks a lot more appealing. In a single-stack semi-auto, you've got a gun with an overall width under an inch. It would be a great choice for a pocket gun. They are light enough that I bet even a pair of board shorts with good elastic would stay up.
The endless debate over whether a .380 is "enough gun" is bound to re-appear here. Personally, I think that's all crap. A .22 is "enough gun" (providing you don't have a misfire on the first shot, of course). Joe Citizen does not need to be all that concerned about being set upon by a determined assailant. If you pull a gun and start shooting at an assailant, what do you really think will happen next? They will stop what they are doing and try to get away! Even if you are using a mouse gun, everyone within half a mile will hear it. People will investigate. The cops will come. Plus, there are bullets, regardless of how tiny, coming at them with intent!
So, yes, if concealed carry were an option, I would own a .380. I'd keep it for taking walks around the neighborhood, for working in the yard, and for those rare occasions when I had to wear dress slacks. Anytime I had jeans on, I'd stick with a .38 revolver. And anytime I was in the house, a full-sized .357.