Hey Bryston, are you using a scope or iron sights? Is your rifle a Marlin or Winchester (or other)?
With iron sights, especially the bead front and semi-buckhorn rear (as found on Winchesters), 50 yard practical accuracy can be pretty good. At 100, if you are using the same size targets, the practical accuracy can drop off rather dramatically--groups can open up quite a bit, the big bead at 100 yards makes it tough to place shots accurately.
Mechanical accuracy is a different thing--if you've locked your rifle into a vise (for example) and got 1" groups at 50, you would stand a good chance of getting 2" groups at 100 because the human error is mostly removed. Of course, no one shoots from a vise at KokoHead.
If you are using a scope, your groups at 100 ought to be smaller but you'll need to check everything on your rifle first--all screws tight (rifle and scope mounts), bore thoroughly cleaned, fouling shots fired, barrel warm or cold, sandbag rests firmly positioned, etc.
It can take a lot of practice to get good at shooting small groups at 100 yards, especially at KokoHead with the winds! Once the range opens up you'll be able to get more practice in, then you can diagnose your rifle and loads more effectively. Making changes in your load after just one or two outings can lead you to chasing your own tail, so to speak.
The 5" drop you experienced--were you getting 2-3 inch groups at 100 that were landing 5" low? Or were your groups opening up to 4-6" at 100 and you were measuring the drop of the center of the group?