I have been doing some research on Ivermectin as it pertains to use to treat COVID-19. Instead of using the WHO or FDA or Fauci which are all controlled by political pundits I decided to use the NIH (National Institutes of Health) which is self described as “A part of the U.S. Department of Health and Human Services, NIH is the largest biomedical research agency in the world.” and does not appear to be taken over by any political powers (yet). Here is what I found:
The creators of Ivermectin and Ivermectin itself won a Nobel Prize in 2015.
I also discovered that there are presently numerous ongoing clinical trials of the use of Ivermectin in the treatment of COVID-19: Including here in the US. “Ivermectin is an FDA-approved broad-spectrum antiparasitic agent with demonstrated antiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).”
I suggest everyone try and read the commentary portion of the webpage I linked below. It is not an easy ready but I will quote some things to prove that Ivermectin has all the right properties for the treatment of COVID-19. This is why there are numerous clinical trials going on right now all over the world. Not to see if it is effective. But to determine how effective. Because it has already been determined to have all the properties necessary to treat COVID-19.
Here are some quotes I took from the commentary:
“The 2015 Nobel Prize in Physiology and Medicine was awarded to William C. Campbell and Satoshi Ömura for their discoveries leading to ivermectin [1]. In addition to its extraordinary efficacy against parasitic diseases, ivermectin continues to offer new clinical applications due to its ability to be repurposed to treat new classes of diseases. Beyond its invaluable therapeutic role in onchocerciasis and strongyloidiasis, an increasing body of evidence points to the potential of ivermectin as an antiviral agent.”
“Recently, Caly et al. reported on the antiviral activity of ivermectin against SARS-CoV-2, the causative agent of COVID-19 [9]. These authors demonstrated that a single dose of ivermectin was able to reduce the replication of an Australian isolate of SARS-CoV-2 in Vero/hSLAM cells by 5000-fold. This finding has generated great interest and excitement among physicians, researchers and public health authorities around the world.”
“In light of the potential of ivermectin to prevent replication in a broad spectrum of viruses, the inhibition of importin α/β1-mediated nuclear import of viral proteins is suggested as the probable mechanism underlying its antiviral activity [6]. Since SARS-CoV-2 is an RNA virus, a similar mechanism of action may take place [9]. A possible ionophore role for ivermectin has also been reported [13]. Since ionophore molecules have been described as potential antiviral drugs [14], ivermectin could ultimately induce an ionic imbalance that disrupts the potential of the viral membrane, thereby threatening its integrity and functionality.”
“In addition to the indication for antiviral therapy, anti-inflammatory intervention may also be necessary to prevent acute lung injury in SARS-CoV-2 infection. With regard to its anti-inflammatory properties, ivermectin have been shown to mitigate skin inflammation [20]. Importantly, ivermectin significantly diminished the recruitment of immune cells and cytokine production in BALF assessed in a murine model of asthma [21]. A study evaluating the ability of ivermectin to inhibit lipopolysaccharide (LPS)-induced inflammation revealed significantly decreased production of TNF-alpha, IL-1ss and IL-6 in vivo and in vitro [22]. Further studies may establish the role of ivermectin on inflammatory response caused by SARS-CoV-2, whether besides the antiviral activity ivermectin could play a supportive adjuvant role facing the hostile infection microenvironment.”
“We hypothesize that micro- and nanotechnology-based systems for the pulmonary delivery of ivermectin may offer opportunities for accelerating the clinical re-purposing of this “enigmatic drug” in the context of SARS-CoV-2 infection, as recent advances in pharmaceutical technology and nanomaterials can be applied to the treatment of pulmonary infections [[24], [25], [26],[36], [37], [38], [39], [40]]. Despite the challenges faced in developing these drug delivery carriers, and uncertainty with regard to the efficacy of ivermectin, it indeed presents promising potential. In an optimistic scenario, new drug dosage forms may not only contribute to mitigate SARS-CoV-2 infection, but also be effective against other emerging viral diseases.”
See Table 1 for a list of only some of the countries doing clinical trials.
There is a lot more to tell. Like dosage size may be a problem. But, apparently an injectable version and a nasal version may show more promise. I know that Israel is working on a nasal delivery system for the treatment and possible propolactic uses of COVID-19 treatments.
To sum up with my limited understanding of how it works, it seems that COVID-19 uses the same transport method that parasites do to move throughout the body. Therefore, Ivermectin helps block the COVID-19 virus from spreading and infecting the body due to the blocking characteristics of Ivermectin. Also, considering its anti-inflammatory characteristics it seems that Ivermectin has the properties to be a great treatment for COVID-19. This why so many countries including the US are either in the process of clinical trials or are just starting clinical trials. So it seems that Ivermectin would be a great choice to do some clinical trials on in order to determine how effective it may be and eventually get approval from our own FDA for its use against COVID-19. Ivermectin is an inexpensive medication here in the US. Insurance copays, if any, are minimal. Ivermectin is obviously showing great promise so numerous countries are testing it. Anything the fake news media says otherwise is in itself, fake news.
The title of this study is: “Ivermectin: an award-winning drug with expected antiviral activity against COVID-19” Expected is the key word here. They already know the potential ivermectin has to become a treatment for COVID-19. Without the results of all these clinical trials, we just don’t know how effective it will be.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539925/